Want to counter the effects of our modern-day oxidative stress that contributes to fatigue, aging, brain fog, and cell damage?
The oxidative stress load and toxic burden of the modern day leave our cells frequently overwhelmed resulting in high oxidative stress levels and down the path toward chronic disease and accelerated aging.
Glutathione is a powerful antioxidant made by all our body’s cells and affects every body system. It is often referred to as “the master antioxidant” and is one of the most amazing natural protective substances discovered. Its immense health benefits include detoxifying the liver, lungs, intestines, and kidneys. It can enhance immunity, well-being, mood, and skin.
Glutathione can help your cells remove heavy metals, cancer cells, and organic and inorganic compounds from inside your cells. The body manufactures it, but the body can only produce a set amount. Our glutathione levels diminish as a result of aging, chronic disease, stress, and toxin exposure. Without enough glutathione production to keep up with the rate of its use by the body’s cells, our systems become overwhelmed with oxidation and ultimately over-inflamed.
Ultraviolet exposure is one of the most important factors contributing the skin hyperpigmentation. Glutathione’s skin-lightening effects have been thought to be related to its ability to suppress free radicals associated with melanin production which is triggered by ultraviolet exposure.
Additionally, research has demonstrated glutathione depletion has been associated with multiple medical conditions including emphysema, asthma, allergic disorder, drug toxicity, metabolic disorders, cancer, chemotherapy, and HIV. Glutathione is currently being investigated as a potential therapeutic agent in the treatment of Parkinson’s disease (PD).
GLUTATHIONE AND PARKINSON'S
Oxidative stress is a known and significant contributor to the development of PD. PD, which is a progressive neurodegenerative disorder, is associated with the presence of Lewy bodies and the loss of dopaminergic neurons within the substantia nigra. Research suggests that glutathione may play a crucial role in protecting dopaminergic neurons from oxidative stress. It plays a critical role as a mediator of oxidative stress within the substantia nigra. Lower levels of glutathione in the substantia nigra of postmortem PD patients relative to age-matched controls have been demonstrated. In contrast, glutathione levels in other parts of the brain remained unchanged.
Given glutathione levels are inversely related to PD disease severity, and are depleted early in the course of PD, as well as its ability to protect the brain from oxidative stress, it has been hypothesized glutathione may be an effective therapy in treating PD.
Researchers administered 600 mg of intravenous glutathione twice daily for 30 days to early-stage, treatment-naïve Parkinson’s patients, all nine of the patients improved during the study with a 42% decline in disability, in an open-label, small-scale study. The benefits lasted 2-4 months after discontinuation of the infusions.
In a randomized, double-blind, placebo-controlled trial, 1400 mg of intravenous glutathione or placebo three times per week for four weeks to 20 individuals with Parkinson’s disease was administered. Although at the conclusion of the study, the Unified Parkinson’s Disease Rating Scale (UPDRS) (a widely applied index of disease severity) scores weren’t significant, the group that received glutathione did experience improvements in UPDRS ADL, and motor subscores during the duration of the study. Eight weeks following the study, the glutathione group demonstrated a worsening of those scores.
While glutathione is not absorbed orally, N-acetyl cysteine can be helpful in facilitating glutathione production. However, glutathione intravenously has 100% absorption and is well-tolerated and can help counter the effects of our modern-day oxidative stress and result in immense health benefits include, including detoxifying the liver, lungs, intestines, and kidneys. It can enhance immunity, well-being, mood, and skin.
https://pubmed.ncbi.nlm.nih.gov/27088927/
https://www.acam.org/blogpost/1092863/185777/Glutathione-and-Parkinson-s-Disease
Comments