Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in almost all cells of the body. NAD+ is required for cellular function and is vital to energy metabolism. It is directly involved in making the ATP within our cell’s “powerhouse” known as the mitochondria. ATP (adenine trisphosphate) is the energy currency essential to life.
Unfortunately, our body’s natural NAD+ diminishes with age, resulting in less available energy for proper cellular functioning. This leads to the cell's inability to clean up free radicals and subsequently results in cellular malfunctioning. When our cells do not function properly, they are termed “senescent” cells. The more senescent cell we have the more aging, metabolic disease, autoimmune disease, neurodegenerative disease, and cancer ensue.
As we age, as well as with chronic illness, trauma, or post-infection, we commonly experience decreased physical performance, increased recovery time, fatigue, diminished brain function, weight gain, more frequent pain and injury, loss of skin elasticity, and wrinkles. Many of us simply write this off as “ just a part of getting old. " While these symptoms are unquestionably associated with aging, there are therapies such as NAD+ that can help to pause the aging process, reverse chronic disease, and ultimately help us to feel better.
NAD+ has been referred to as “The foundation of youth.” It has been safely administered and researched for decades. There has been a surge of recent interest in NAD+ biology, with the recognition that NAD+ influences many biological processes beyond metabolism. NAD+ is ubiquitous and essential for optimal cellular and biological function. https://pubmed.ncbi.nlm.nih.gov/29883761/
Not only does it contribute to improvements in performance, recovery, aging, anxiety, sleep, autoimmune disease, and neurodegenerative disease, NAD+ can actually help repair neurons in the brain resulting in improved mental clarity, alertness, concentration, and memory. This can be particularly helpful in reducing symptoms associated with Alzheimer’s and Parkinson’s disease.
NAD+ / Neurodegenerative Disease
Research by (Hou et al, 2018), was able to demonstrate that NAD supplementation normalized neuroinflammation while improving synaptic transmission resulting in improved learning, memory, and motor function. https://pubmed.ncbi.nlm.nih.gov/29432159
NAD was demonstrated to have beneficial clinical effects for 80% of patients receiving supplementation in another study on Parkinson's disease. https://pubmed.ncbi.nlm.nih.gov/8101414/
NAD+/ Chronic Fatigue, Post-Viral Brain Fog
Today, so many people struggle with difficulty concentrating, focusing, memory problems, or overall feeling a haziness or decrease in mental clarity. These symptoms are commonly related to excess oxidative stress, poor diet, lack of sleep, and overall poor health. NAD+ works at the cellular level to facilitate cellular function and energy production which in turn reduces oxidative burden.
NAD+ Pain, Fibromyalgia, CRPS, DDD
NAD+ performs a major role in the inflammatory response and antioxidant behavior There is a family of proteins called Sirtuins. Certain sirtuins can reduce inflammation and consequently, alleviate pain. These proteins are associated with NAD+ as they require NAD+ to function properly. When our body is lacking sufficient quantities of NAD, there is a possibility of increased pain.
As you can see, NAD+’s health benefits are vast, making it an essential component to add to your wellness tool kit. It can restore appropriate neurotransmission in the brain, help fight oxidative stress, optimize your body with ATP production, and give you that extra boost you need to get moving again. NAD+ works synergistically with lifestyle & nutrient optimization. One of the most effective ways to replenish your body’s NAD+ stores is through IV administration. IV NAD+ infusions offer 100% bioavailability. NAD+ is the crème de la crème when it comes to optimizing cellular function allowing us to feel, perform, and age better!
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